Analysis of information flow network during episodic memory retrieval

Chung-Yeon Lee and Byoung-Tak Zhang

Abstract

Episodic memory formation is associated with large-scale neuronal activity distributed across the cortex. Decades of neuroimaging and patient lesion studies demonstrated the correlation between the roles of specific brain structures in episodic memory retrieval. Distributed, coordinated and synchronized activities across brain regions have also been investigated. However, neuronal mechanisms based on effective connectivity underlying the coordination of this anatomically distributed information processing into introspectively coherent cognition have remained largely unknown. Here we investigate the information flow network of the human brain during episodic memory retrieval. We have estimated local oscillation amplitudes and asymmetric inter-areal synchronization from EEG recordings in individual cortical anatomy by using source reconstruction techniques and effective connectivity methods during episodic memory retrieval. The strength and spectro-anatomical patterns of these inter-areal interactions in sub-second time-scales reveal that the episodic memory retrieval involves the increase of information flow and densely interconnected networks between the prefrontal cortex, the medial temporal lobe, and some subregions of the parietal cortex. In this network, interestingly, the SFG acted as a hub, globally interconnected across broad brain regions.